Epigenetic Shift and Modus Vivendi
Tabernanthe iboga with its alkaloid ibogaine is recognized in the West as a remedy against diverse addictions, while traditionally it is used as inductor of maturation. Its uniqueness lays in the multiple actions – it triggers psychedelic insights, facilitates metabolic adaptations and sets new spiritual habitus. Our study was a quest for common denominator for these seemingly diverse effects through investigation of ibogaine’s influence on gene expression. The induction of energy metabolism related enzymes and facilitated shifts in homeostasis were found. While various drugs of abuse interfere with energy metabolism findings suggest that facilitated detoxification, tolerance reversion and craving elimination are related to restoration of satisfactory bioenergetics. Pharmacology of ibogaine and risk reduction measures should be evident to all who are about to enter such process; either self-healing, personal growth, spiritual insights, recreational use or just mere curiosity.
Roman Paškulin M.D., PhD. is a founder of OMI Institute for anthropological medicine and researcher in the Laboratory for Neuroregeneration at the University of Ljubljana. His doctorate thesis “Pharmacodynamics of Entheogene Drugs – Influence on Gene Expression” is a study on the impact of ibogaine on cellular metabolism. This scientific approach of evaluation of natural remedies aims to bring traditional knowledge into Western medical use. His special interests lie in the lifestyle diseases, especially addiction and most of his work deals with the »soul healing« herbs. He has conducted field researches on iboga, ayahuasca, and mandrake ethnopharmacology and is author of a series of scientific publications that bridge molecular genetics with physiological, psychosocial and spiritual impact of entheogen use. As a medical hypnosis therapist he offers counseling on the risk reduction and success improvement of altered states related therapies.