Ibogaine and addiction in the animal model, a systematic review and meta-analysis
Ibogaine is a naturally occurring substance which has been increasingly used in the lay-scene to reduce craving and relapse in patients with substance use disorders (SUDs). Although human clinical trials on the safety and efficacy of ibogaine are lacking, animal studies do support the efficacy of ibogaine. In a systematic review and meta-analysis we have summarized these animal findings, addressing three questions: 1) does ibogaine reduce addictive behaviour in animal models of SUDs?; 2) what are the toxic effects of ibogaine on motor functioning, cerebellum and heart rhythm?; 3) what are neuropharmacological working mechanisms of ibogaine treatment in animal models of SUDs? We will present the conclusions of our findings.
Maarten Belgers, Medical Doctor in Addiction Medicine (Master in Addiction Medicine KNMG) at Iriszorg. Researcher at Iriszorg and Radboud University Medical Center.